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Push the plunger so the air goes into the bottle. Put the needle into the rubber top of that insulin bottle.Pull back the plunger of the syringe to put as much air in the syringe as the dose of the longer-acting insulin. Take the cap off the needle, being careful not to touch the needle to keep it sterile. Know the dose of each insulin you are going to use.Wipe the top of the bottle with an alcohol wipe. If the vial has a plastic cover, take it off.This is the amount of insulin you should have in the syringe before injecting it. Your doctor will tell you how much of each insulin you will need.You will also be told which insulin to draw up first. Never mix two types of insulin in one syringe unless you are told to do this.To fill a syringe with two types of insulin: Put the syringe down carefully so the needle does not touch anything. When there are no bubbles, take the syringe out of the bottle.Push the bubbles back into the insulin bottle, then pull back to get the right dose. If there are bubbles, hold both the bottle and syringe in one hand, and tap the syringe with your other hand. With the tip of the needle in the liquid, pull back on the plunger to get the right dose of insulin into the syringe.Keep the needle in the bottle and turn the bottle upside down.Put the needle into and through the rubber top of the insulin bottle.Pull back the plunger of the syringe to put as much air in the syringe as the dose of medicine you want.

Know the dose of insulin you are going to use.If the insulin vial has a plastic cover, take it off.Clear insulin does not need to be mixed.Intermediate-acting insulin (N or NPH) is cloudy and must be rolled between your hands to mix it.If it does, throw it out and get another bottle. The insulin should not have any clumps on the sides of the bottle.To fill a syringe with one type of insulin: Gather your supplies: insulin, needles, syringes, alcohol wipes, and a container for used needles and syringes.Once you have started using a vial of insulin, it can be kept at room temperature for 28 days. If you have stored it in the refrigerator or cooler bag, take it out 30 minutes before the injection. Insulin should be given at room temperature.

Always try to use the same brands and types of supplies.

Ask your provider if this system would be good for you.

Many types of insulin come in an injection system called an insulin pen.

Magnifiers are available that clip to your syringe to make the markings easier to see.

If you are having trouble seeing the markings on the syringe, talk to your provider or CDE.

Some insulins will not work if mixed with other insulins. Check with your provider or pharmacist about this.

Some types of insulin can be mixed with each other in one syringe, but many cannot be mixed.

Do not mix or dilute concentrated insulin with any other insulin. Insulin syringes or concentrated insulin are now widely available. Because U-500 syringes may be difficult to find, your provider may give you instructions for using U-500 insulin with U-100 syringes.

More concentrated insulins are available.

Every small notch on a standard 1 mL insulin syringe is 1 unit of insulin. Most insulin syringes are marked for giving you U-100 insulin.

Standard insulin contains 100 units in 1 mL.

The type of insulin should match the type of syringe: Know the name and dose of each medicine to give.